Project 5 - Monitoring Endoplasmic Reticulum Stress Caused by Chronic Exposure to Chemicals
Project Leader:
Dr. Fawaz Haj, Professor
Senior investigator:
Dr. Bruce Hammock, Professor
Dr. Christophe Morisseau, Research Scientist
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Within the goals of the UC Davis Superfund Center, this project will investigate new mechanistic insights into the effects of chronic exposure of Superfund (SF) chemicals on endoplasmic reticulum (ER) stress, which leads to fibrosis and organ damage. Recent and exciting data demonstrate that exposure to xenobiotics perturbs the levels of P450-generated lipid mediators, which directly affect the pathological development of ER stress. Thus, this project will directly test the novel hypothesis that plasma lipid mediators may represent a surrogate biomarker for ER stress following chronic xenobiotic exposure, as well as developing a new cell-based bioassay for quantitation of pro-ER stress environmental toxicants in field samples.
2010 - Most Recent
2005 - 2010 Project Period
231 Novel Pathway Involved in Neurodevelopmental Toxicity of PCBs
225 Commercial Paper and Rubber Products Contain Activators of the Aryl Hydrocarbon Receptor
213 Widely Used Antibacterial Agents May Lead to Significant Health Concerns
204 CALUX Generation 3 - Enhanced Sensitivity for Low Volume/Low Concentration Samples
Personnel
Project Narrative
Publications
Research Brief