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Project 4 - Critical Role of Mitochondrial Oxidative Stress (MOS) in Chemical Induced Cardiac Toxicity
Project Leader:
Dr. Nipavan Chiamvimonvat, Professor
Senior investigator:
Dr. Aldrin Gomes, Professor
This project will investigate the molecular mechanisms of chronic exposure to Superfund (SF) chemicals on mitochondrial oxidative stress (MOS) and proteasome dysfunction, which can lead to fibrosis, cell death and organ damage. The Specific Aims of this project will directly test the novel hypothesis that oxidized proteins and impaired proteasome and immunoproteasome activities may represent a surrogate biomarker for MOS following chronic xenobiotic exposure.
2010 - Most Recent
2005 - 2010 Project Period
Personnel
Project Narrative
Publications
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